Working principle of high-efficiency wet mixing granulator:
The high-efficiency wet granulation machine adopts a large amount of the latest technology on the basis of the original granulation at home and abroad, and has the characteristics of reasonable organic structure, convenient use, and complete functions.
Characteristics of high-speed mixing granulator:
1. Adopting a horizontal cylindrical structure with a reasonable structure;
2. Inflatable sealed drive shaft, can be switched to water during cleaning;
3. Fluidized granulation, resulting in approximately spherical particles with good flowability;
4. Reduce adhesive by 25% compared to traditional processes and shorten drying time;
5. Each batch is dry mixed for 2 minutes and granulated for 1-4 minutes, which increases efficiency by 4-5 times compared to traditional processes;
6. Completed in the same closed container, dry mixing wet mixing granulation, process reduction, in compliance with GMP standards;
7. The entire operation has strict safety protection measures.
Common methods and characteristics of high-speed mixing granulators:
Granulation methods commonly include wet granulation, one-step granulation, and dry granulation. Granulation is the process of mixing raw material powders with binders to form soft materials, and drying the particles. However, the traditional method for producing soft materials is to use a trough mixing mechanism to produce soft materials and then use a swinging particle mechanism to wet the particles. However, using a drying oven to dry the soft materials into dry particles results in low yield, high strength, serious pollution, long production cycle, and large equipment footprint. Recently, it has gradually been replaced by the continuous production operation method or one-step granulation method of high-speed mixing granulator and boiling drying granulation.
Functional requirements for high-speed mixing granulator:
1. The mixing blade is used to dry mix the materials, followed by wet mixing after adding adhesive. The rotation speed of the stirring blade can be adjusted according to the characteristics of the material and adhesive to ensure the generation of vortices and thorough mixing of the materials. At the same time, the intersection area of the granulation knife fully breaks down the churning material into particles;
2. The rotation speed of the stirring blade and granulation knife can cause three-dimensional motion of the material, resulting in collision, friction, and shear of particles, making the friction uniform and fine, and finally forming stable spherical particles. The mixing time, speed of the stirring blade and granulation knife, quality and uniformity of granulation after drying meet the requirements of the solid preparation production process;
3. The process should be in a closed state, and the entire mixing and granulation process (including feeding, mixing, cutting and granulation, unloading, etc.) should work at a cleanliness level of 100000 or 300000, and ensure that no foreign objects fall down;

4. The machine can be paired with boiling drying or lifting feeding or vacuum feeding equipment.

Technical Specifications